There's no better place in the Big Easy to "laissez les bons temps rouler" than the city's infamous Bourbon Street. You can admire the historic, Spanish-with-a-dash-of-French architecture during the day, but the neighborhood truly comes alive when the sun sets. Take advantage of the lack of open container laws and grab hand grenades at Tropical Isle, daiquiris at Fat Tuesday, or hurricanes at Pat O'Brien's. Or if you're more into music than booze, there's Fritzel's or Irvin Mayfield's, and history nerds can soak up the atmosphere at the Old Absinthe House or Lafitte's Blacksmith Shop. And remember to hydrate, for Pete's sake.